{"product_id":"reishi-mushroom","title":"Reishi Mushroom","description":"\u003cp dir=\"ltr\"\u003e\u003cem\u003e\u003cstrong\u003eDosage:\u003c\/strong\u003e 1-2 dropperful per day in juice or water\u003c\/em\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eIngredients:\u003c\/strong\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eOrganic Reishi Mushroom \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eGrain Alcohol \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e \u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003cspan\u003eAvoid if allergic to any ingredients \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eReishi is also known as \u003c\/span\u003e\u003cspan\u003eLing Zhi, \u003c\/span\u003e\u003cspan\u003ethe Mushroom of Immortality, and was revered by the Chinese for its positive tonifying effects. β-glucans help to prime a weakened immune system, enhancing protection from repeated acute infections as well as more chronic immune disorders, increasing T-lymphocytes, TNF-α, IL-1-β, IL-2, and IL-6 production. As well as medicinal mushrooms, β-glucans are also found as the brown spots on apples and pears, and actively prime the immune system.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAllergies, liver support, cancer (especially breast and prostate), hypertension, anxiety\/insomnia. Together with \u003c\/span\u003e\u003cspan\u003eCordyceps sinensis\u003c\/span\u003e\u003cspan\u003e, \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e has the most extensive range of indications and combines well with it in treatment of lung and liver conditions, as well as to provide all-round adaptogenic support.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eCancer\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e has a long history of traditional use in the treatment of cancer and is credited with many cases of spontaneous remission (22, 23). As well as the immune modulating effect of its high polysaccharide content, its triterpenes show significant cytotoxic activity against different cancer cell lines, as well as inhibitory effects against Epstein-Barr virus, known to be associated with some cancers (24-35). In addition triterpenes from \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e show inhibition of the nuclear transcription factor, NF-kappaB (NF-kB), which is overexpressed in various cancer cell lines, and also theAP-1 signalling pathway (36).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eInhibition of NF-kB is of particular importance in the activity of \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e against breast and prostate cancers as it is considered to play an essential role in the hormone independent growth and spread of these cancers (37,38). In addition\u003c\/span\u003e\u003cspan\u003e G. lucidum\u003c\/span\u003e\u003cspan\u003e triterpenes have been shown to block the androgen receptor on prostate cancer cells, supporting \u003c\/span\u003e\u003cspan\u003eG.lucidum\u003c\/span\u003e\u003cspan\u003e’s use in the treatment of prostate cancer.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eClinical studies with \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e polysaccharide extract confirm its ability to enhance immune status in cancer patients with increases in NK cell activity and Th1 cytokine levels and decreases in Th2 cytokine levels in advanced lung cancer patients, and reduction in side effects when given alongside chemotherapy and radiotherapy (39-41).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIn vitro\u003c\/span\u003e\u003cspan\u003e and \u003c\/span\u003e\u003cspan\u003ein vivo\u003c\/span\u003e\u003cspan\u003e studies also indicate significant anti-tumour activity for the triterpenerich \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e spore powder and spore oil5, (42-46). A randomized controlled trial of 48 breast cancer patients reported reductions in fatigue, anxiety and depression in the treatment group (3g\/day \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e spore powder), together with improvements in immune parameters (47).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eAllergies\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAs well as immunomodulatory activity, \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e demonstrates strong anti-inflammatory activity with suppression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), the inflammatory mediator nitric oxide (NO) and prostaglandin E2, mediated through inhibition of the NF-kB andAP-1 signaling pathways. This combination of immunomodulatory and anti-inflammatory activity contributes to its efficacy in the treatment of allergies and other inflammatory conditions (48-51). \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e is a component of FAHF-2, a Chinese herbal formula that has been reported to completely block anaphylactic reactions in a mouse model of peanut allergy (52).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eLiver disease\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe fruiting body of \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e has long been a popular traditional treatment for liver diseases and demonstrates wide hepatoprotective properties (53-59). It appears that at least part of its action in this regard may be through the ability of \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e triterpenes to block platelet-derived growth factor beta receptor (PDGFbetaR), thus inhibiting the activation and proliferation of hepatic stellate cells, a key event in hepatic fibrosis (60). \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e is also traditionally used in the treatment of hepatitis and in a clinical study of 355 cases of hepatitis B treated with Wulingdan Pill, of which \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e is the major component, 92.4% of patients were reported to have positive results (61). Again, it appears that triterpenes are the key components (62,63).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eHypertension\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e has a broad range of action on cardiovascular health. Polysaccharides and triterpenes isolated from \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e have shown hyperlipidaemic, hypotensive, and anti-thrombotic effects while a polysaccharide preparation (Ganopoly) led to improved ECG and lowered chest pain, palpitation and shortness of breath in a double-blind, randomized, multi-centre study64. MildACE-inhibitory activity has also been demonstrated for some of \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e’s triterpenoid compounds (65,66).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eInsomnia \/ Anxiety\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe traditional name ‘spirit mushroom’ points to the sedative action of its triterpenoid components and many herbalists value its benefits in cases of insomnia. Christopher Hobbs recommends \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e for deficiency insomnia while Mizuno recommends it for ‘mental stabilisation’ (67-70).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eRheumatoid arthritis\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e’s combination of immuno-modulatory and anti-inflammatory action suggests potential application in the treatment of autoimmune conditions such as rheumatoid arthritis and a proteoglycan fraction from \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e has been shown to inhibit production of rheumatoid arthritis synovial fibroblasts \u003c\/span\u003e\u003cspan\u003ein vitro\u003c\/span\u003e\u003cspan\u003e, in part through inhibition of the NF-kB transcription pathway (71).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eNeuro-protective\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTraditionally considered to promote longevity, \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e extract has been shown to inhibit beta-amyloid synaptic toxicity with potential benefits in Alzheimer’s disease (72). Both polysaccharides and triterpenes from \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e exhibit neuroprotective and anticonvulsant effects at levels of 10-80mg\/kg while \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e spores have shown ability to protect neurons from apoptosis and improve cognitive dysfunction \u003c\/span\u003e\u003cspan\u003ein vivo (\u003c\/span\u003e\u003cspan\u003e73-77).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eAnti-aging\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTraditionally known as the ‘mushroom of immortality’, \u003c\/span\u003e\u003cspan\u003eG. lucidum\u003c\/span\u003e\u003cspan\u003e’s broad-spectrum cardiovascular, neurological and immunological benefits, together with its support for blood sugar and cholesterol control (79-82), contribute to its anti-ageing properties.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePatients on anti-coagulant medication should be monitored due to G. lucinum’s actions in this area although a study of G. lucidum supplementation (1.5g\/day) in healthy volunteers showed no effect on hemostatic function \u003c\/span\u003e\u003c\/p\u003e","brand":"Root \u0026 Leaf Holistic","offers":[{"title":"Default Title","offer_id":52592994681199,"sku":null,"price":22.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/rootandleafholistic.com\/products\/reishi-mushroom","provider":"Root \u0026 Leaf Holistic","version":"1.0","type":"link"}